Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
J. Clin. Invest. Xueliang Du, et al. 116:1071 doi:10.1172/JCI23354 [Go to this article.]

Figure 3
Effect of CPT-I inhibition, UCP-1, and MnSOD on FFA-induced ROS production. Cells were incubated in 5 mM glucose alone or in 5 mM glucose plus either oleic acid alone or oleic acid plus either tetradecylglycidate (TDGA), adenoviral vectors expressing uncoupling protein 1 (UCP-1), or adenoviral vectors expressing manganese superoxide dismutase (MnSOD). Each bar represents the mean plus SEM of 4 separate experiments, each with n = 8. *P < 0.01 compared with cells incubated in 5 mM glucose alone.