Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice
J. Clin. Invest. Robert P. Brendza, et al. 115:428 doi:10.1172/JCI23269 [Go to this article.]

Figure 5
Repeated-measures ANOVA on data derived from 23 neuritic plaques imaged from 10 different untreated PDAPP;YFP transgenic mice and 18 plaques imaged from 7 different 10D5-treated PDAPP;Thy-1:YFP transgenic mice. All dystrophic neurites were imaged on day 0 and then reimaged on day 3. A significant treatment × day interaction for both the mean number [F_1,28 = 25.092, P = 0.00003] of dystrophic neurites (A) and the mean total cross-sectional area [F_1,28 = 21.037, P = 0.00009] of dystrophic neurites (B) was seen. In the absence of treatment, dystrophic neurites did not undergo significant changes in regard to number or cross-sectional area over a 72-hour period. However, a significant decrease in both mean number and mean cross-sectional area was seen in animals receiving 10D5 treatment. *P < 0.00005 versus untreated group.