Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice
J. Clin. Invest. Robert P. Brendza, et al. 115:428 doi:10.1172/JCI23269 [Go to this article.]

Figure 2
Reimaging of a neuritic plaque in a living PDAPP;Thy-1:YFP double-transgenic mouse. (A and B) A single neuritic plaque imaged through a cranial window in a living PDAPP;Thy-1:YFP double-transgenic mouse with 2-photon microscopy on the initial day of surgery. (C and D) The same plaque shown in A and B, imaged 3 days after surgery. Multiple neurites of normal caliber and dystrophic neurites (arrows) were easily visualized with YFP fluorescence (green). A and C show both methoxy-X04–labeled amyloid (blue) and YFP-labeled neurites. B and D are identical to A and C, respectively, but only show the YFP signal. In the absence of any treatment, the relative number and size of amyloid-associated dystrophic neurites did not significantly change over a 72-hour period. Each panel is a projection of multiple focal planes that span approximately 20 μm. Scale bar: 20 μm.