Rap1b is required for normal platelet function and hemostasis in mice
J. Clin. Invest. Magdalena Chrzanowska-Wodnicka, et al. 115:680 doi:10.1172/JCI22973 [Go to this article.]

Figure 5
Impaired soluble and solid-phase fibrinogen binding to Rap1b-null platelets. (A) Specific soluble fibrinogen binding to Rap1b-null platelets, presented relative to that of normal platelets, arbitrarily set at 100%, in the presence of the indicated concentrations of ADP. (B) Specific soluble fibrinogen binding to Rap1b-null platelets, relative to that of normal platelets, in the presence of AYPGKF peptide. (C) Wild-type and Rap1b-null platelet spreading on fibrinogen-coated coverslips in the absence (FGN) or presence (FGN + epi) of epinephrine. Data represent mean ± SEM (n > 30). P < 0.0001 by t test compared with control.