Organ-specific roles for transcription factor NF-κB in reovirus-induced apoptosis and disease
J. Clin. Invest. Sean M. O’Donnell, et al. 115:2341 doi:10.1172/JCI22428 [Go to this article.]

Figure 6
Heart pathology following reovirus infection of p50^+/+ and p50^–/– mice. (A and B) Newborn p50^+/+ and p50^–/– mice were inoculated perorally with either PBS (mock) (A) or 10⁴ PFU reovirus T3SA⁺ (B), and heart size was monitored at 2-day intervals. Percent heart weight was calculated as heart weight divided by body weight. The results are expressed as the mean heart weights of at least 4 animals for each time point. Error bars indicate SDs. *P < 0.05 by Student’s t test. (C) Hearts from mice euthanized 12 days following peroral inoculation with reovirus T3SA⁺ or gelatin saline (Mock). (D, E, and F) Electrocardiography and echocardiography of reovirus-infected p50^–/– (D), mock-infected p50^–/– (E), and reovirus-infected (F) p50^+/+ mice. Newborn mice were inoculated perorally with 10⁴ PFU T3SA⁺, and tests were performed 10 days after inoculation. A P-wave/QRS ECG complex is displayed above the corresponding echocardiographic image. Systolic and diastolic LV cavity dimensions are indicated by bars superimposed on the M-mode images.