Acute renal failure: definitions, diagnosis, pathogenesis, and therapy
J. Clin. Invest. Robert W. Schrier, et al. 114:5 doi:10.1172/JCI22353 [Go to this article.]

Figure 5
Potential cytoskeletal targets of cysteine proteases during hypoxia/ischemia in proximal tubules. The basolateral membrane of the proximal tubules contains the subunits of Na⁺/K⁺-ATPase, which are linked to the actin cytoskeleton by ankyrin and spectrin. This forms a metabolically stable complex. Potential cytoskeletal targets of cysteine proteases during hypoxia/ischemia are shown. Ank, ankyrin; CAM, cell adhesion molecule; 4.1, protein 4.1. Figure reproduced with permission from Taylor & Francis (36).