Muscle-specific expression of IGF-1 blocks angiotensin II–induced skeletal muscle wasting
J. Clin. Invest. Yao-Hua Song, et al. 115:451 doi:10.1172/JCI22324 [Go to this article.]

Figure 6
Angiotensin II–induced muscle loss in WT mice is associated with (A) reduced levels of phospho-Bad in gastrocnemius muscle; (B) increased cytochrome c release into the cytosolic fraction (*P < 0.05, angiotensin II–infused vs. pair-fed WT); and (C) DNA fragmentation as detected by cell death ELISA (**P < 0.01, angiotensin II–infused vs. pair-fed WT). These changes were completely blunted in the transgenic mice (A–C).