Muscle-specific expression of IGF-1 blocks angiotensin II–induced skeletal muscle wasting
J. Clin. Invest. Yao-Hua Song, et al. 115:451 doi:10.1172/JCI22324 [Go to this article.]

Figure 4
Skeletal muscle–specific expression of an IGF-1 transgene blocks angiotensin II–induced wasting. WT or transgenic (Tg) mice were either angiotensin II infused or sham infused and pair fed for 7 days, and daily weights were measured (A and B) and muscle weights obtained at 7 days (C–E). The relative weight loss in angiotensin II–infused WT mice (A; *P < 0.01 WT/angiotensin II–infused vs. WT/pair-fed) was blocked in transgenic mice (B) with preferential fast-fiber effect (C and D).