Muscle-specific expression of IGF-1 blocks angiotensin II–induced skeletal muscle wasting
J. Clin. Invest. Yao-Hua Song, et al. 115:451 doi:10.1172/JCI22324 [Go to this article.]

Figure 1
Angiotensin II produces muscle wasting in mice. C57BL/6 mice were either angiotensin II infused or sham infused and pair fed. Angiotensin II (A) markedly increased blood pressure (*P < 0.001, angiotensin II–infused vs. pair-fed), (B) produced relative weight loss (**P < 0.01 angiotensin II–infused vs. pair-fed), and (C and D) reduced muscle mass (***P < 0.05, angiotensin II–infused vs. pair-fed). A, angiotensin II–infused; P, pair-fed.