PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic β cells
J. Clin. Invest. Naoko Hashimoto, et al. 115:138 doi:10.1172/JCI22232 [Go to this article.]

Figure 4
Lack of effect of β cell–specific ablation of PKCλ on islet morphology and insulin content. (A) Immunostaining of pancreatic sections from 6-month-old control and βPKCλ^–/– mice with antibodies against insulin (red) and glucagon (green). Scale bars: 50 μm. (B) Quantitation of β cell area as a percentage of total pancreatic area in control and βPKCλ^–/– mice. Data are means ± SE of values from 4 mice of each genotype. (C) Insulin content of isolated islets. Data are means ± SE of values from 4 mice of each genotype. (D) Electron microscopy of β cells of control and βPKCλ^–/– mice. Magnification, ×10,000.