Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer
J. Clin. Invest. Jennifer D. Wu, et al. 114:560 doi:10.1172/JCI22206 [
Go to this article.]
Figure 2Immunohistochemical staining of MIC on human prostate biopsies. (
A) No MIC immune reactivity in a benign prostate. (
B and
C) Predominant surface MIC immune reactivity in prostate secretory epithelia of HGPIN (
B) and GS 5–6 prostate carcinoma (
C). (
D–
F) MIC staining was no longer abundantly present on carcinoma cell surface and diffuse stromal MIC immuoreactivity was shown in high-grade cancers (GS 8–10). Original magnification, ×40.
