Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis
J. Clin. Invest. Antonella Contri, et al. 115:369 doi:10.1172/JCI22094 [Go to this article.]

Figure 1
Analysis of protein tyrosine phosphorylation in normal and CLL B cells. Immunoblot analysis of cellular tyrosine-phosphorylated proteins in normal B cells, from both tonsil (T) and peripheral blood (P), and in leukemic B-CLL cells. Cells were lysed, and the proteins were analyzed by Western blotting (Wb) and immunostaining with antibody against phosphorylated tyrosine. The filter was reprobed with anti–β-actin antibody as loading control. The molecular mass of protein standards is indicated on the right. The data are representative of experiments performed with 3 different tonsils, 5 peripheral blood samples, and 40 B-CLL samples.