Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
J. Clin. Invest. Peter Baluk, et al. 115:247 doi:10.1172/JCI22037 [
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Figure 6Persistence of new lymphatic vessels after treatment. (
A and
B) Weight of lungs and bronchial lymph nodes (
A) and abundance of tracheal lymphatic vessels and blood vessels (
B) in pathogen-free mice (0), mice infected with
M. pulmonis for 2 or 4 weeks (2 and 4), and mice infected for 2 weeks and then treated with oxytetracycline for 2 to 12 weeks (2 + 2 through 2 + 12). The weight of both organs increased after infection and decreased toward normal after treatment. Airway blood vessels (green) showed a similar pattern, whereas lymphatic vessels (red) proliferated after infection but regressed little, even after 12 weeks of treatment. *
P < 0.05 vs. pathogen-free group;
P < 0.05 vs. 2-week-infected group without treatment. (
C and
D) Confocal micrographs showing tracheal lymphatic vessels (red) and blood vessels (green) after infection for 2 weeks and then oxytetracycline treatment for 8 weeks. Blood vessels regressed almost to the pathogen-free state. Lymphatic vessels showed some changes but regressed only slightly; lymphatic vessels with constrictions and no LYVE-1 immunoreactivity in some cells are indicated by arrows. (
D) Enlargement of the boxed area in
C. Scale bar in
D applies to both figures: 100 μm in
C, 25 μm in
D.
