PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
J. Clin. Invest. Rohit N. Kulkarni, et al. 114:828 doi:10.1172/JCI21845 [
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Figure 2Alterations in acute phase response to glucose and glucose tolerance. (
A and
B) Acute phase insulin secretory response to intraperitoneal (i.p.) injection of glucose was measured in mice after a 14-hour overnight fast. *
P < 0.05, WT vs. PDX-1, IR/PDX-1, IRS-1/PDX-1, or TKO; _
P < 0.05, IRS-1 or IR/IRS-1 vs. WT (
n = 4_10). (
C_
F) Glucose tolerance after intraperitoneal injection of glucose was measured after a 14-hour fast in 2-month-old (
C and
D) and 4-month-old (
E and
F) male mice. In 2-month-old mice, *
P < 0.05, IRS-1/PDX-1 or TKO vs. PDX-1;
P < 0.05, PDX-1 vs. WT. In 4-month-old mice, *
P < 0.05, IRS-1/PDX-1 or TKO vs. WT; P < 0.05, IR/IRS-1 or PDX-1 vs. WT (
n = 7_18).
