The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity
J. Clin. Invest. David G. Bowen, et al. 114:701 doi:10.1172/JCI21593 [Go to this article.]

Figure 1
Early activation of naive CD8⁺ Des-TCR T cells occurred independently within the liver and LNs of Met-K^b mice. CFSE-labeled Des-TCR LN cells were adoptively transferred into Met-K^b and control B10.BR mice, and organs were harvested 2 hours 15 minutes later. Lymphocytes isolated from blood, liver, spleen, and LNs were analyzed by flow cytometry. Representative histograms show CD69 expression by CFSE⁺ CD8⁺ CD44^low cells within a forward and side scatter gate appropriate for lymphocytes.