Cardiac adenoviral S100A1 gene delivery rescues failing myocardium
J. Clin. Invest. Patrick Most, et al. 114:1550 doi:10.1172/JCI21454 [Go to this article.]

Figure 4
Normalization of Ca²⁺ transients and SR Ca²⁺ load after S100A1 gene delivery in FCs. (A) Original tracings of Ca²⁺ transients (shown as upward deflection) from a representative NFC, FC, FC-AdGFP, and FC-AdS100A1. (B) Normalization of Ca²⁺-transient amplitude (nM) and (C) significant decrease in diastolic [Ca²⁺] (nM) in failing cells after AdS100A1 treatment (n = 40 cells from 4 different preparations in each group). (D) Original tracings of cytosolic Ca²⁺ rise in response to acute caffeine application (10 mM) in the presence of Ni²⁺ (5 mM) (shown as upward deflection) from a representative NFC, FC, FC-AdGFP, and FC-AdS100A1. (E) Normalization of SR Ca²⁺ load estimated from the caffeine-induced cytosolic Ca²⁺ rise (nM) in FCs after AdS100A1 gene transfer (n = 40 cells from 4 different preparations in each group). *P < 0.01 compared with NFCs; **P < 0.01 compared with FCs and FCs-AdGFP; P = NS, NFCs vs. FCs-AdS100A1. Data are presented as mean ± SEM.