Cardiac adenoviral S100A1 gene delivery rescues failing myocardium
J. Clin. Invest. Patrick Most, et al. 114:1550 doi:10.1172/JCI21454 [Go to this article.]

Figure 1
Postinfarct heart failure model. (A) Representative TTC-stained cross-sections of a sham-operated (Sham-OP, left) and a cryoinfarcted (Cryo-MI, right) rat heart 6 hours after surgery. Transmural cryoinfarcted myocardium emerges as brown tissue with a gray-white border zone (right). Scale bar: 5 mm. (B) Representative mid-ventricular cross sections of a sham-operated (left) and cryoinfarcted (right) rat heart 12 weeks after surgery. Scale bar: 1 mm. (C) Representative images of a freshly isolated LV cardiomyocyte from a nonfailing sham-operated (NFC, left) and cryoinfarcted failing heart (FC, right) 12 weeks after surgery. Note the marked increase in end-diastolic length in the FC. Scale bar: 25 μm.