Apolipoprotein A-IV inhibits experimental colitis
J. Clin. Invest. Thorsten Vowinkel, et al. 114:260 doi:10.1172/JCI21233 [
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Figure 11Histology (H&E staining; magnification, ×100) of colonic samples from WT mice receiving either water (control) or DSS, and from
ApoA-IV–/– animals receiving DSS or DSS + 0.5 mg rhA-IV. Compared with WT control animals (
A), colon of WT DSS-treated mice (
B) showed only mild inflammation (arrows), whereas in
ApoA-IV–/– animals, DSS alone (
C) produced loss of epithelial lining (arrowheads), edema (asterisk), and severe cellular inflammation (arrows). Treatment of DSS-treated
ApoA-IV–/– animals with 0.5 mg rhA-IV prevented morphological damage and cellular infiltration (
D).
