Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A–deficient mice
J. Clin. Invest. Maria Rosaria Cera, et al. 114:729 doi:10.1172/JCI21231 [Go to this article.]

Figure 8
Increased CHS response in Jam-A ^–/– mice. (A) Animals were sensitized with OXA on their shaved abdominal skin and 5 days later were challenged on the right ear. Ear swelling was measured and expressed as percent increase over controls (left ear was painted with vehicle alone). The control mean values ± SEM were comparable: 23.86 × 10^–2 ± 0.46 × 10^–2 mm for Jam-A^+/+ mice and 23.50 × 10^–2 ± 0.28 × 10^–2 mm for Jam-A ^–/– mice. The values reported in the figure are mean ± SEM (8 mice per group) of one representative experiment out of three performed (*P ≤ 0.05 and **P < 0.01 by Student’s t test). (B) Jam-A^+/+ mice were immunized by subcutaneous injection of DNBS-loaded DCs obtained from Jam-A^+/+ or Jam-A ^–/– mice (see Methods). Mice were challenged 5 days later by ear painting with DNFB. Figures represent the percent increase of ear swelling over controls. Mean values ± SEM (8 mice per group) of one representative experiment out of three performed are shown (*P ≤ 0.05 and **P < 0.01 by Student’s t test). Mean ± SEM of vehicle-treated ears was comparable between both groups (22.63 × 10^–2 ± 0.26 × 10^–2 mm for Jam-A^+/+ and 22.25 × 10^–2 ± 0.16 × 10^–2 mm for Jam-A ^–/– mice).