Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A–deficient mice
J. Clin. Invest. Maria Rosaria Cera, et al. 114:729 doi:10.1172/JCI21231 [Go to this article.]

Figure 7
Increased in vivo migration of cutaneous DCs in Jam-A ^–/– mice. (A) Time course of recruitment of FITC⁺/CD11c⁺ DCs in lymph nodes (LN) following FITC skin painting. Results represent the mean ± SEM of a single experiment (seven mice per group) out of four performed (*P < 0.01, **P < 0.001 by Student’s t test). The percentages of FITC⁺/CD11c⁺ DCs in lymph nodes were 1.0 ± 0.14 for Jam-A^+/+ mice and 0.8 ± 0.12 for Jam-A ^–/– mice at time 0; 2.76 ± 0.45 for Jam-A^+/+ mice and 5.01 ± 1.09 for Jam-A ^–/– animals at 6 hours, and 2.28 ± 0.28 and 4.94 ± 0.46 for Jam-A^+/+ and Jam-A ^–/– mice, respectively, at 24 hours. (B) Recruitment of FITC⁺/CD11c⁺ DCs in lymph nodes of Tie-2 Cre Jam-A ^–/– mice 24 hours after FITC skin painting. Results are mean ± SEM of one representative experiment (eight mice per group) out of three performed.