Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-γ in experimental biliary atresia
J. Clin. Invest. Pranavkumar Shivakumar, et al. 114:322 doi:10.1172/JCI21153 [
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Figure 9Impaired expression of chemokines following RRV challenge of
IFN-γ
–/– mice. Hepatic mRNA expression for downstream targets of IFN-γ as a ratio to GAPDH shows a lower increase for IP-10 (
A) and I-Tac (
B) 7 days after RRV challenge, and a complete suppression of Mig (
C). *
P < 0.05 and **
P < 0.001 when WT is compared to
IFN-γ
–/– mice;
n = 4–7 mice for each group and at all time points.
