Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-γ in experimental biliary atresia
J. Clin. Invest. Pranavkumar Shivakumar, et al. 114:322 doi:10.1172/JCI21153 [
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Figure 7Persistent infiltration of portal space by neutrophils in
IFN-γ
–/– mice. RRV challenge induces a neutrophil-based pericholangitis within 3 days in WT and
IFN-γ
–/– mice (
A and
B). In WT mice, inflammatory cells switch to lymphocytes in expanded portal spaces 7–14 days after challenge (
C and
E). This switch is incomplete in
IFN-γ
–/– mice, which continue to display portal neutrophils (
D and
F). Arrows point to neutrophils.
