Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-γ in experimental biliary atresia
J. Clin. Invest. Pranavkumar Shivakumar, et al. 114:322 doi:10.1172/JCI21153 [Go to this article.]

Figure 6
Administration of recombinant IFN-γ results in obstruction of extrahepatic bile ducts in IFN-γ^–/– mice. H&E staining of transverse sections along the extrahepatic bile duct of an IFN-γ^–/– mouse that received daily intraperitoneal injections of 2,000 U of recombinant IFN-γ per gram body weight following RRV challenge. (A) A patent proximal segment of the duct. (B) A narrow lumen with increasing periductal inflammation (approximately 700 μm from the section in A). (C) Section approximately 100 μm from the section in B; the inflammation completely occludes the extrahepatic bile duct. Magnification ×200.