Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-γ in experimental biliary atresia
J. Clin. Invest. Pranavkumar Shivakumar, et al. 114:322 doi:10.1172/JCI21153 [Go to this article.]

Figure 4
Loss of IFN-γ improves symptoms of biliary obstruction after RRV challenge. Inoculation of RRV into newborn WT (A) mice induced jaundice, acholic stools, and bilirubinuria in all mice by 7 days, which persisted for the duration of the study in approximately 80% of mice. Although these symptoms also developed in IFN-γ^–/– mice in a timely fashion (B), jaundice, acholic stools, and bilirubinuria resolved between 8 and 13 days after RRV challenge. n = 17 for WT mice; n = 12 for IFN-γ^–/– mice.