MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs
J. Clin. Invest. Giovanni Sitia, et al. 113:1158 doi:10.1172/JCI21087 [
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Figure 4Induction of collagenase and gelatinase activities within the intrahepatic necroinflammatory foci of CTL-injected mice is inhibited by the enhanced TIMP-1 expression. Collagen type I (A, top panels) and gelatin (B, bottom panels) in situ zymography were performed on liver sections from the same mice described in the legend to Figure
3. Note that no collagenase and gelatinase activity was observed in CTL-injected mice that received the pcDNA3.1-TIMP-1 (right panels). Original magnification, ×400.
