Preclinical deposition of pathological prion protein PrP^Sc in muscles of hamsters orally exposed to scrapie
J. Clin. Invest. Achim Thomzig, et al. 113:1465 doi:10.1172/JCI21083 [Go to this article.]

Figure 2
PET blotting of preclinical cerebral PrP^Sc deposition in the brain stem. The slices comprise the area of the dorsal motor nucleus of the vagus nerve that provides the initial site of PrP^Sc deposition in the brain of hamsters perorally infected with 263K scrapie (A and B). Animals for which all muscles and the sciatic nerve were found negative for PrP^Sc at 130 days after infection displayed less widespread and intense deposition of PrP^Sc in the brain stem (A) than observed in the corresponding brain region (B) of animals already showing PrP^Sc in their muscle tissue. Scale bars in A and B, 500 ∝m.