The eosinophil enigma
J. Clin. Invest. Timothy J. Williams, et al. 113:507 doi:10.1172/JCI21073 [
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Figure 1Role of eosinophil-derived TGF-β
1 in lung remodeling. Eosinophils in the asthmatic lung release latent TGF-β
1. Latent TGF-β
1 (latTGF-β
1) is activated by α
vβ
6 expressed on airway epithelial cells. TGF-β
1 mediates airway remodeling by inducing the formation of myofibroblasts that secrete extracellular matrix proteins, and the growth factor also stimulates airway smooth muscle hyperplasia.
