A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice
J. Clin. Invest. Eric Marietta, et al. 114:1090 doi:10.1172/JCI21055 [
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Figure 3Direct immunofluorescence analysis of the cellular infiltration of lesional skin. (
A–
E) Lesional sections of the ear of an NOD Abo DQ8+ mouse that had developed gluten-dependent blisters. (
A) H&E staining. Original magnification, ×20. (
B) Anti–7/4 staining of epidermis from a lesional mouse. Original magnification, ×20. (
C) Isotype control. Original magnification, ×20. (
D) Anti–neutrophil elastase staining of the epidermis and upper dermis of a lesional mouse. Original magnification, ×20. (
E) Isotype control. Original magnification, ×20. Arrows in the upper dermis identify elastase-containing neutrophils.
