Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
J. Clin. Invest. Mitsuhiro Watanabe, et al. 113:1408 doi:10.1172/JCI21025 [
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Figure 2CA lowers hepatic TGs in KK-
Ay mice. (
A) Liver morphology, H&E-stained liver sections (HE), and Oil Red O_stained liver sections (OR) in animals treated with the indicated diets for 3 weeks. When sacrificed, the mice were 9 weeks old. (
B) Liver TG and (
C) cholesterol content after 3 weeks on the different diets (age 9 weeks,
n = 5). (
D) In vivo VLDL secretion from the livers of mice on the different diets (age 7 weeks,
n = 4) or after treatment with GW4064 (age 12 weeks,
n = 4). C, control diet; C + CA, control diet with CA; HF, high-fat diet; HF + CA, high-fat diet with CA.
