Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
J. Clin. Invest. Mitsuhiro Watanabe, et al. 113:1408 doi:10.1172/JCI21025 [
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Figure 1CA lowers serum TGs in KK-
Ay mice. (
A) Food intake of KK-
Ay mice during 1 week on the diets as described in the figure. Serum levels of TGs, total cholesterol (Chol), and FFA in KK-
Ay mice after 1 week on the different diets (age 7 weeks,
n = 5). Kcal, kilocalories; BW, body weight. (
B) TG and cholesterol lipoprotein profiles after size-exclusion chromatography of serum pools from five animals. The quantification of the VLDL TGs is shown in an inset. (
C) Serum TGs in KK-
Ay (top, age 12 weeks,
n = 4) and
ob/
ob (bottom, age 12 weeks,
n = 4) mice after 0, 1, 3, and 7 days of treatment with the synthetic FXR agonist GW4064. *
P < 0.05; **
P < 0.01 throughout the figures.
