Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
J. Clin. Invest. Roderick J. Phillips, et al. 114:438 doi:10.1172/JCI20997 [Go to this article.]

Figure 2
Kinetics of Col I and Col III gene expression and total collagen protein deposition in the lung during bleomycin-induced pulmonary fibrosis. (A and B) Kinetics of pro-Col I (A) and pro–Col III (B) gene expression in lungs of mice exposed to intratracheal bleomycin compared with saline control as determined by real-time quantitative PCR. n = 6 lungs in each group. Data represent the mean ± SEM. *P < 0.05, significant differences between bleomycin and saline groups. ct, threshold cycle number. (C) Kinetics of total collagen protein deposition in lungs of mice exposed to either intratracheal bleomycin, saline, or naive (time 0) control as determined by the Sircol assay. n = 6 lungs in each group. Data represent the mean ± SEM. *P < 0.05, significant differences between bleomycin and saline groups.