Hepatitis C virus mutation affects proteasomal epitope processing
J. Clin. Invest. Ulrike Seifert, et al. 114:250 doi:10.1172/JCI20985 [Go to this article.]

Figure 3
NS3_1073–1081 epitope–specific CD8⁺ T cells recognize aminoterminally extended, but not carboxyterminally extended, peptides of the minimal optimal NS3_1073–1081 epitope. NS3_1073–1081–specific CD8⁺ T cells were expanded from PBMCs of an HCV-recovered patient by several weeks of peptide stimulation and tested against amino- and carboxyterminally extended peptides in a standard ⁵¹Cr-release assay. The mutant sequence at AA position 1082 is underlined.