A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
J. Clin. Invest. Rolf Postina, et al. 113:1456 doi:10.1172/JCI20864 [
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Figure 4Analysis of amyloid deposits in brains from 17- to 19-month-old double-transgenic
ADAM10-mo ∞
APP[V717I] (
A and
B) and
ADAM10-dn ∞
APP[V717I] mice (
C and
D). Isolated tiny (
A) and diffuse (
B) amyloid deposits in the brain of an
ADAM10-mo ∞
APP[V717I] mouse. Immunohistochemistry was performed with antibodies 6F/3D (
A) and 4G8 (
B), detecting either only Aβ peptides or Aβ peptides in addition to N-terminally truncated Aβ peptides (p3 fragments). Scale bars: 100 ∝m. (
C and
D) Analysis of amyloid plaque composition in the brain of an
ADAM10-dn ∞
APP[V717I] mouse. Immunohistochemistry was performed with antibodies FCA3542 (
C) and FCA3340 (
D), detecting peptides containing Aβ
X-42 and Aβ
X-40, respectively. Antibody FCA3340 detects fewer plaques than FCA3542 does. Scale bars: 200 ∝m.
