Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease
J. Clin. Invest. Timothy S. Olson, et al. 114:389 doi:10.1172/JCI20855 [
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Figure 7B cell population expansion correlates with disease severity in SAMP1/YitFc mice. (
A) Percentages of CD4
+ T cells (black) and CD19
+ B cells (white) within MLNs (mean ± SEM) of individual SAMP1/YitFc mice (
n = 20) in which the total inflammatory score of the distal ileum was greater than 10 (mean ± SEM = 15 ± 1;
n = 14) or less than 10 (mean ± SEM = 5 ± 1;
n = 6). *CD4
+ T cell and B cell percentages are significantly different (
P < 0.02) between the two groups. (
B) The percentage of B cells in MLNs of mice (
n = 20) correlates (
r = 0.7) with the villus distortion component of the histopathological scoring index.
