Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease
J. Clin. Invest. Timothy S. Olson, et al. 114:389 doi:10.1172/JCI20855 [Go to this article.]

Figure 4
Correlation between B cell expansion and αEβ7⁺CD4⁺ T cells. (A) Left, correlation (r = 0.6) between B cell number as a percentage of all MLN cells and the percentage of MLN CD4⁺ cells expressing αE in individual SAMP1/YitFc mice (n = 21). Right, comparison of the percentage of B cells in MLNs of mice with αE⁺CD4⁺ cells comprising greater than versus less than 15% of the MLN CD4⁺ population (line represents mean). (B) Representative CD4⁺-gated dot plot and average quadrant percentages (n = 10) showing expression of β7 integrin versus ICOS on SAMP1/YitFc MLN CD4⁺ T cells.