Bmi1, stem cells, and senescence regulation
J. Clin. Invest. In-Kyung Park, et al. 113:175 doi:10.1172/JCI20800 [Go to this article.]

Figure 1
Postulated Bmi1 targets. Extrinsic signals for a stem cell to self-renew result in elevation of the Bmi1 level in stem cells. This allows repression of various genes including the Ink4a locus genes, p16Ink4a and p19Arf, and possibly activation, via indirect mechanisms, of some genes including telomerase, apoptosis inhibitor-6 (Ai6), and platelet-activating factor acetylhydrolase (PAF-AHγ). These genes are likely play a role in stem cell fate decisions including self-renewal and differentiation. *Sites of frequent mutations associated with cancer. TJP, tight junction protein. RDC1, chemokine orphan receptor 1.