Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats
J. Clin. Invest. Hiroaki Satoh, et al. 114:224 doi:10.1172/JCI20785 [
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Figure 2Hyper-resistinemia impairs glucose tolerance. GTT (
A and
B) and ITT (
C) in male Wistar rats on day 7 after Adv injection. Glucose (
A) and insulin (
B) concentrations from the GTTs of rats injected with Adv-lacZ (open circles;
n = 8) or Adv-resistin (filled circles;
n = 8) that were then injected with 2 g glucose/kg body weight after a 6-hour fast. (
C) Glucose curves for the ITTs of rats injected with Adv-lacZ (open circles;
n = 8) or Adv-resistin (filled circles;
n = 8) that were then injected with 0.75 U human insulin/kg body weight after a 6-hour fast. Plasma glucose levels were normalized to those at 0 minutes in each group (100%). **
P < 0.05.
