Antagonistic antibody prevents toll-like receptor 2–driven lethal shock-like syndromes
J. Clin. Invest. Guangxun Meng, et al. 113:1473 doi:10.1172/JCI20762 [
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Figure 6Inhibitory effect of mAb T2.5 on host activation by microbial challenge in vivo. Mice were pretreated i.p. with 1 mg mAb T2.5 (black bars) or left untreated (white bars). Mice were challenged i.p. with P
3CSK
4 and
D-galactosamine after 1 hour and sacrificed 2 or 4 hours later (
n = 4 for each group at each time point). Serum concentrations of TNF-α (
A), GROα/KC (human IL-8 homolog) (
B), IL-6 (
C), and IL-12p40 (
D) were analyzed by ELISA. *
P < 0.05, **
P < 0.005, ***
P < 0.001, Student’s
t test for unconnected samples.
