Antagonistic antibody prevents toll-like receptor 2–driven lethal shock-like syndromes
J. Clin. Invest. Guangxun Meng, et al. 113:1473 doi:10.1172/JCI20762 [Go to this article.]

Figure 2
Subcellular localization of TLR2 in vitro. Monoclonal antibody T2.5 was used for cytochemical detection of overexpressed mTLR2 and human TLR2 (hTLR2) (A), as well as endogenous murine (TLR2^+/+, wild-type) or human TLR2 in primary macrophages (B). Vector-transfected HEK293 cells as well as TLR2^–/– primary macrophages were analyzed as controls. Concanavalin A (ConA) was used for staining of cellular membranes. The bar in the lower right corner of each field represents a distance of 20 ∝m (A) or 10 ∝m (B) on the slides analyzed.