Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction
J. Clin. Invest. Sara Weis, et al. 113:885 doi:10.1172/JCI20702 [Go to this article.]

Figure 1
Src blockade protects following myocardial infarction. (A) pp60Src–/– mice have significantly reduced myocardial water content and infarct size 24 hours after MI. (B) MRI T2 maps overlaid on gradient echo images in rats treated with vehicle or the PP1 Src inhibitor. Scale at right indicates T2 values from red (lower T2) to blue (higher T2). T2 values greater than 40 milliseconds were used as an index of edema, and representative images reveal reduced volume containing T2 values greater than 40 milliseconds 24 hours following MI in PP1-treated rats. Graph shows significant differences of the percentage of LVs with T2 values greater than 40 milliseconds between vehicle- and SKI-606 treated rats. (C) Treatment with a Src inhibitor results in significant and dose-dependent decreases in myocardial water content and infarct size after MI. Single-dose treatment with a Src inhibitor was optimally effective in reducing infarct size when administered 45 minutes after LAD ligation and still reduced infarct size significantly when administered up to 6 hours after infarct. (D) Src inhibition reduces infarct size and preserves function following transient ischemia and reperfusion. All panels represent the Src inhibitor PP1, except for B, as noted, and D, right panel, in which the Src inhibitor SKI-606 was used. *P < 0.05; **P < 0.001.