Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors
J. Clin. Invest. Frédéric Preitner, et al. 113:635 doi:10.1172/JCI20518 [Go to this article.]

Figure 3
IPGTTs (1 mg/g). (a) Glycemic excursions in 3- to 4-month-old male WT (n = 9), Glp-1R–/– (n = 12), Gipr–/– (n = 19), and double-KO (n = 17) mice. Insets: quantification as AUC of the glycemic excursions. (b) Glycemic excursions in 10-month-old male WT (n = 6) and double-KO (n = 10) mice. Insets: quantification as AUC of the glycemic excursions. (c) Glycemic excursions in 3- to 4-month-old female WT (n = 7), Glp-1R–/– (n = 11), Gipr–/– (n = 9), and double-KO mice (n = 11). Insets: quantification as AUC of the glycemic excursions. (d) Plasma insulin levels in female mice at basal state and at 2 and 30 minutes after intraperitoneal glucose injection (n = 4–9). Data, pooled from two to four separate experiments, are expressed as means ± SE. *P < 0.05, §P < 0.005 vs WT controls. #P < 0.05 vs. double-KO.