VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment
J. Clin. Invest. Claus Cursiefen, et al. 113:1040 doi:10.1172/JCI20465 [Go to this article.]

Figure 3
Neutralization of VEGF-A inhibits HA and lymphangiogenesis. (A–F) A molecular trap designed to bind VEGF-A (VEGF Trap_R1R2) completely inhibits both HA and lymphangiogenesis within 1 week after injury. Whereas mice receiving an intraperitoneal injection of Fc protein at surgery (Fc control) display robust angiogenesis (A, slit-lamp picture; B, CD31 staining) and lymphangiogenesis (C, CD31 and LYVE-1 staining) 1 week later, mice treated with a single injection of VEGF Trap_R1R2 do not show HA (D and E; blood vessels are green) or lymphangiogenesis (F; lymph vessels are red). Magnification, ×100 (C–F). (G) Morphometric analysis of the nearly complete inhibitory effect of VEGF Trap on both HA and lymphangiogenesis (P < 0.001). Magnification (A and B), ×20.