Smooth muscle cell–extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy
J. Clin. Invest. Matthew T. Wheeler, et al. 113:668 doi:10.1172/JCI20410 [
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Figure 4Vascular spasm is present in
dsg–/– and
gsg–/– but not in
dsg–/–/MHD or
gsg–/–/MHG animals. Microvascular filling defects were seen in
dsg–/– and
gsg–/– animals at similar frequencies. Examples of focal narrowings are shown (arrows). In contrast, no focal narrowings were ever seen in
dsg–/–/MHD and
gsg–/–/MHG animals. Well-filled vascular trees with smoothly tapered vessels are shown at lower power (bottom row).
