Bacterial flagellin is a dominant antigen in Crohn disease
J. Clin. Invest. Michael J. Lodes, et al. 113:1296 doi:10.1172/JCI20295 [Go to this article.]

Figure 9
Adoptive transfer of C3H/HeJBir CD4⁺ CBir1-specific T cell line into C3H/HeJ scid/scid recipients. (A) Two months after transfer, cecal and colon histopathology was assigned scores with a quantitative system (14). CD4⁺ T cells activated polyclonally with mAb against CD3 prior to transfer were used as a negative control (Anti-CD3_activated). A CBA-specific CD4⁺ T cell line reactive with unselected cecal bacterial antigens was used as a positive control (CBA-specific T cell line); the CBir1-specific CD4⁺ T cell line corresponds to the flagellin-specific T cell line in Figure 8. Sample size (n) is indicated at the top. (B) Representative histopathology of the groups shown in A: Anti-CD3_activated CD4⁺ T cells (top panel), CBir1 flagellin_specific CD4⁺ T cells (middle panel), and CBA-specific CD4⁺ T cells (bottom panel). Magnification, ∞200.