Bacterial flagellin is a dominant antigen in Crohn disease
J. Clin. Invest. Michael J. Lodes, et al. 113:1296 doi:10.1172/JCI20295 [Go to this article.]

Figure 3
Western blot analysis of the serum antibody response to recombinant flagellins CBir1 and Fla-X and their fragments. (A) Noncolitic C3H/HeJ (pool of two) versus colitic C3H/HeJBir (pool of five) mice. (B) Noncolitic FVB (pool of five) versus colitic mdr1a^–/– (pool of five) mice. (C) Random human blood donor (Normal human) versus a pool of CD patients with severe disease. Protein samples include mouse CBA, full-length recombinant proteins (FL), the NH₂ conserved region (A) and the conserved carboxy region (C) of flagellin (see Figure 2, C and D).