Direct evidence for a β1-adrenergic receptor–directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy
J. Clin. Invest. Roland Jahns, et al. 113:1419 doi:10.1172/JCI20149 [
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Figure 4Echocardiography of rat hearts. Digitally stored representative M-mode and Doppler images demonstrating (
A) nonmarked and (
B) online marked M-mode tracings from the same animal, off-line measured end-diastolic and end-systolic LV diameters (LVED/LVES) from (
C) an anti–β
1-EC
II-positive and (
D) a corresponding control animal (immunization experiment, month 15), and on-line determination of (
E) LV outflow tract diameter (LVOT; M-mode tracings) and (
F) aortic VTI in a same animal (Doppler tracings).