Direct evidence for a β₁-adrenergic receptor–directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy
J. Clin. Invest. Roland Jahns, et al. 113:1419 doi:10.1172/JCI20149 [Go to this article.]

Figure 1
Study protocol and anti–β₁-AR Ab’s. (A) The plotted curve indicates mean titers plus or minus SEM (error bars) of specific rat anti–β₁-EC_II (IgG subclass) during the immunization experiment. Time points of subcutaneous immunizations are indicated by arrows. The inset depicts the immunoreactivities of IgG prepared from all 15 β₁-EC_II–injected rats 3 months after the first immunization determined by ELISA. (B) Scheme depicting concentrations of rat anti–β₁-EC_II (serum pool and transferred amounts) during the transfer experiment. Time points of intravenous serum transfer are indicated by arrows. The inset shows representative mean titers plus or minus SEM after transfer of 0.7 ∝g anti–β₁-EC_II/g BW over a 4-week period and the derived half-life for rat anti–β₁-EC_II.