Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury
J. Clin. Invest. Lixin Sun, et al. 113:1364 doi:10.1172/JCI20001 [
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Figure 8SCF-stimulated progenitor cell migration in vivo. (
A and
B) Whole-brain image of DiI labeling after ventricular injection of DiI. DiI-labeled cells (red) were only detected in the lining of ventricular zone. Boxed regions in
A are shown at higher magnification in
B. DiI staining was confined to the nuclei and process of cells. (
C and
D) Representative images of control hemisphere (
C) and SCF-injected hemisphere (
C). Note the greater number of DiI-positive cells in the SCF injection side. (
E) Whole-brain image of GFP-positive cells (green) in the brain. 3V, third ventricle. (
F and
G) Representative images of control hemisphere (
F) and SCF-injected hemisphere (
G). Scale bar (shown in
B):
A and
E, 100 ∝m;
B_
D, F, and
G, 20 ∝m.
