Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy
J. Clin. Invest. Sachiko Shinoda, et al. 113:1059 doi:10.1172/JCI19971 [Go to this article.]

Figure 2
Activation of FKHR/FKHRL-1 following seizures. (A) Representative Western blot (n = 2 per lane) showing that levels of phosphorylated (p) FKHRL-1 and FKHR are lower in hippocampal samples obtained 40 minutes after seizure induction (seiz) than in controls. The graph below shows quantitative change (fold vs. control) for pFKHR. *P < 0.05 vs. control. Data are from six rats per group. (B) Representative Western blots (n = 2 per lane) showing that hippocampal expression levels of other BH3-only proteins (Bad and Bid) and forkhead targets (p27^Kip1, FasL, and manganese superoxide dismutase [MnSOD]) are not increased by seizures. Immunoblots are representative of two or three independent experiments.