Central and peripheral actions of somatostatin on the growth hormone–IGF-I axis
J. Clin. Invest. Robert D. Murray, et al. 114:349 doi:10.1172/JCI19933 [Go to this article.]

Figure 3
Octreotide suppresses hepatic IGF-I in vitro and in vivo. (A) Isolated rat hepatocytes incubated with vehicle or GH (500 ng/ml) in the presence and absence of 100 nM SRIF or octreotide. Medium was collected after 24 hours and assayed for IGF-I content by RIA after acid-alcohol extraction. (B) Rat livers perfused ex vivo with Krebs buffer with or without 0.5 μg/ml GH in the presence or absence of octreotide (20 ng/g body wt/h) for 60 minutes. GH was perfused from minutes 15–25 and octreotide from minutes 0–60. *P < 0.05 compared with control; ^#P < 0.05 compared with GH-perfused livers.